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Bacterial recognition by PGRP-SA and downstream signalling by Toll/DIF sustain commensal gut bacteria in Drosophila

Abstract:

The gut sets the immune and metabolic parameters for the survival of commensal bacteria. We report that in Drosophila, deficiency in bacterial recognition upstream of Toll/NF-κB signalling resulted in reduced density and diversity of gut bacteria. Translational regulation factor 4E-BP, a transcriptional target of Toll/NF-κB, mediated this host-bacteriome interaction. In healthy flies, Toll activated 4E-BP, which enabled fat catabolism, which resulted in sustaining of the bacteriom...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pgen.1009992

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Role:
Author
ORCID:
0000-0002-8294-0308
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Role:
Author
ORCID:
0000-0002-3819-2023
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ORCID:
0000-0002-1893-1212
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Role:
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ORCID:
0000-0001-6360-3878
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ORCID:
0000-0001-7105-2498
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Genetics Journal website
Volume:
18
Issue:
1
Article number:
e1009992
Publication date:
2022-01-10
Acceptance date:
2021-12-14
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
Pmid:
35007276
Language:
English
Keywords:
Pubs id:
1232139
Local pid:
pubs:1232139
Deposit date:
2022-03-22

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