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Journal article

Endolysosomal two‐pore channels regulate autophagy in cardiomyocytes

Abstract:

Key points

  • Two‐pore channels (TPCs) were identified as a novel family of endolysosome‐targeted calcium release channels gated by nicotinic acid adenine dinucleotide phosphate, as also as intracellular Na+ channels able to control endolysosomal fusion, a key process in autophagic flux.
  • Autophagy, an evolutionarily ancient response to cellular stress, has been implicated in the pathogenesis of a wide range of cardiovascular pathologies,...
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    Publication status:
    Published
    Peer review status:
    Peer reviewed

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    Publisher copy:
    10.1113/JP271332

    Authors


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    Publisher:
    Wiley Publisher's website
    Journal:
    Journal of Physiology Journal website
    Volume:
    594
    Issue:
    11
    Pages:
    3061-3077
    Publication date:
    2016-01-12
    Acceptance date:
    2015-12-28
    DOI:
    EISSN:
    1469-7793
    ISSN:
    0022-3751
    Pmid:
    26757341
    Source identifiers:
    586968
    Language:
    English
    Keywords:
    Pubs id:
    pubs:586968
    UUID:
    uuid:6b6950c0-5466-4d00-8d82-bd71f1c9316c
    Local pid:
    pubs:586968
    Deposit date:
    2017-03-12

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