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Journal article

Mice develop normally in the absence of Smad4 nucleocytoplasmic shuttling.

Abstract:

Smad4 in partnership with R-Smads (receptor-regulated Smads) activates TGF-beta (transforming growth factor-beta)-dependent signalling pathways essential for early mouse development. Smad4 null embryos die shortly after implantation due to severe defects in cell proliferation and visceral endoderm differentiation. In the basal state, Smad4 undergoes continuous shuttling between the cytoplasm and the nucleus due to the combined activities of an N-terminal NLS (nuclear localization signal) and ...

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Publication status:
Published

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Publisher copy:
10.1042/bj20061830

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Biochemical journal More from this journal
Volume:
404
Issue:
2
Pages:
235-245
Publication date:
2007-06-01
DOI:
EISSN:
1470-8728
ISSN:
0264-6021
Language:
English
Keywords:
Pubs id:
pubs:7116
UUID:
uuid:6b64aa87-2ab3-4287-b583-b0c011382f56
Local pid:
pubs:7116
Source identifiers:
7116
Deposit date:
2012-12-19

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