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Infection-induced resistance to experimental cerebral malaria is dependent upon secreted antibody-mediated inhibition of pathogenic CD8(+) T cell responses

Abstract:

Cerebral malaria (CM) is one of the most severe complications of Plasmodium falciparum infection. There is evidence that repeated parasite exposure promotes resistance against CM. However, the immunological basis of this infection-induced resistance remains poorly understood. Here, utilizing the Plasmodium berghei ANKA (PbA) model of experimental cerebral malaria (ECM), we show that three rounds of infection and drug-cure protects against the development of ECM during a subsequent fourth (4X)...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3389/fimmu.2019.00248

Authors


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Name:
Wellcome Trust
Grant:
106917/Z/15/Z
Publisher:
Frontiers Media
Journal:
Frontiers in Immunology More from this journal
Volume:
10
Article number:
248
Publication date:
2019-02-19
Acceptance date:
2019-01-29
DOI:
ISSN:
1664-3224
Keywords:
Pubs id:
pubs:977256
UUID:
uuid:6b625d3d-9138-48cc-a634-6973079a85c7
Local pid:
pubs:977256
Source identifiers:
977256
Deposit date:
2019-03-03

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