Virus-induced immunosuppression: immune system-mediated destruction of virus-infected dendritic cells results in generalized immune suppression.

Journal article

Despite the clinical importance of virus-induced immunosuppression, how virus infection may lead to a generalized suppression of the host immune response is poorly understood. To elucidate the principles involved, we analyzed the mechanism by which a lymphocytic choriomeningitis virus (LCMV) variant produces a generalized immune suppression in its natural host, the mouse. Whereas adult mice inoculated intravenously with LCMV Armstrong rapidly clear the infection and remain immunocompetent, in...

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Authors: Borrow, P; Evans, C; Oldstone, M

• Publication status: Published
• Journal: Journal of virology
• Volume: 69
• Issue: 2
• Pages: 1059-1070
• Publication date: 1995-02-01
• EISSN: 1098-5514
• ISSN: 0022-538X
• Language: English
• Keywords: Spleen; Dendritic Cells; T-Lymphocytes, Cytotoxic; Antigen-Presenting Cells; Mice, Inbred BALB C; HIV Infections; Mice; Lymphocytic Choriomeningitis; Cricetinae; Animals; Immune Tolerance; Antigens, CD8