Journal article
siRNA modified with 2′‐deoxy‐2′‐C‐methylpyrimidine nucleosides
- Abstract:
-
(2′S)‐2′‐Deoxy‐2′‐C‐methyluridine and (2′R)‐2′‐deoxy‐2′‐C‐methyluridine were incorporated in the 3′‐overhang region of the sense and antisense strands and in positions 2 and 5 of the seed region of siRNA duplexes directed against Renilla luciferase, whereas (2′S)‐2′‐deoxy‐2′‐C‐methylcytidine was incorporated in the 6‐position of the seed region of the same constructions. A dual luciferase reporter assay in transfected HeLa cells was used as a model system to measure the IC50 values of 24 diff...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1002/cbic.201800077
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Authors
Funding
+ EMBO short-term fellowship
More from this funder
Funding agency for:
Dellafiore, M
Grant:
ASTF 515–2015
Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- ChemBioChem Journal website
- Volume:
- 19
- Issue:
- 13
- Pages:
- 1409-1413
- Publication date:
- 2018-05-30
- Acceptance date:
- 2018-04-14
- DOI:
- EISSN:
-
1439-7633
- ISSN:
-
1439-4227
- Pmid:
-
29656613
- Source identifiers:
-
836610
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:836610
- UUID:
-
uuid:6b5d10ae-b334-47ed-9aca-eb899844c313
- Local pid:
- pubs:836610
- Deposit date:
- 2018-06-07
Terms of use
- Copyright holder:
- Wiley‐VCH Verlag GmbH and Co KGaA, Weinheim
- Copyright date:
- 2018
- Notes:
- Copyright © 2018 Wiley‐VCH Verlag GmbH and Co. KGaA, Weinheim.
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