Internet publication
Tau filaments are tethered within brain extracellular vesicles in Alzheimer’s disease
- Abstract:
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The abnormal assembly of tau protein in neurons is the pathological hallmark of multiple neurodegenerative diseases, including Alzheimer’s disease (AD). In addition, assembled tau associates with extracellular vesicles (EVs) in the central nervous system of patients with AD, which is linked to its clearance and prion-like propagation between neurons. However, the identities of the assembled tau species and the EVs, as well as how they associate, are not known. Here, we combined quantitative m...
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- Publication status:
- Published
- Peer review status:
- Not peer reviewed
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- Files:
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(Preview, Pre-print, pdf, 12.4MB, Terms of use)
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- Publisher copy:
- 10.1101/2023.04.30.537820
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Funding
Bibliographic Details
- Host title:
- bioRxiv
- Place of publication:
- United States
- Publication date:
- 2023-04-30
- Acceptance date:
- 2023-04-30
- DOI:
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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1345034
- Local pid:
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pubs:1345034
- Deposit date:
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2024-02-09
Terms of use
- Copyright holder:
- Fowler et al.
- Copyright date:
- 2023
- Rights statement:
- © 2023 The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
- Notes:
- This is the pre-print version of the article. The final version is available online from bioRxiv at https://dx.doi.org/10.1101/2023.04.30.537820
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