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Journal article

The clinical application of microRNAs in infectious disease

Abstract:

MicroRNAs (miRNAs) are short single-stranded non-coding RNA sequences that posttranscriptionally regulate up to 60% of protein encoding genes. Evidence is emerging that miRNAs are key mediators of the host response to infection, predominantly by regulating proteins involved in innate and adaptive immune pathways. miRNAs can govern the cellular tropism of some viruses, are implicated in the resistance of some individuals to infections like HIV, and are associated with impaired vaccine response...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.3389/fimmu.2017.01182

Authors


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Department:
Oxford, MSD, Paediatrics
O’Connor, D More by this author
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Department:
St Cross College
National Institute for Health Research More from this funder
Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Immunology Journal website
Volume:
8
Pages:
1182
Publication date:
2017-09-05
Acceptance date:
2017-09-06
DOI:
EISSN:
1664-3224
Pubs id:
pubs:731394
URN:
uri:6b5a7820-bfc6-429d-b8e7-8240a4030af2
UUID:
uuid:6b5a7820-bfc6-429d-b8e7-8240a4030af2
Local pid:
pubs:731394

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