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Real-time analysis of nanopore-based metagenomic sequencing from infected orthopaedic devices

Abstract:

Background

Prosthetic joint infections are clinically difficult to diagnose and treat. Previously, we demonstrated metagenomic sequencing on an Illumina MiSeq replicates the findings of current gold standard microbiological diagnostic techniques. Nanopore sequencing offers advantages in speed of detection over MiSeq. Here, we report a real-time analytical pathway for Nanopore sequence data, designed for detecting bacterial composition of prosthetic joint infections but potentiall...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/s12864-018-5094-y

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
NDM Experimental Medicine
Oxford college:
Pembroke College
Role:
Author
ORCID:
0000-0001-6370-1961
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
NDM Experimental Medicine
Role:
Author
ORCID:
0000-0002-9129-3149
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
NDM Experimental Medicine
Role:
Author
Expand authors...
Publisher:
BioMed Central Publisher's website
Journal:
BMC Genomics Journal website
Volume:
19
Issue:
1
Pages:
714
Publication date:
2018-09-27
Acceptance date:
2018-09-19
DOI:
EISSN:
1471-2164
ISSN:
1471-2164
Pubs id:
pubs:922568
URN:
uri:6b580903-3e72-4d8a-b0a8-2dcc825ccf3e
UUID:
uuid:6b580903-3e72-4d8a-b0a8-2dcc825ccf3e
Local pid:
pubs:922568

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