Journal article

Apathy in Alzheimer's disease

Abstract:: Apathy is the most common neuropsychiatric symptom in patients with Alzheimer's disease (AD). The presence of apathy has been related to greater caregiver distress, decreased quality of life, and increased morbidity. Here we review the most recent studies on this neuropsychiatric syndrome, focusing on prevalence, impact on quality of life, behavioural and neuroimaging studies, and treatment options. The results of some investigations on the behavioural and neuroanatomical profile of apathy in AD point to a role of frontostriatal circuits, specifically involving the anterior cingulate cortex. However, small and heterogeneous samples, lack of control for disease severity, and non-specific apathy scales complicate interpretation of results. Future studies might benefit from studying multiple dimensions of apathy within conceptual frameworks which allow for a deconstruction of underlying mechanisms.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Nobis, L., & Husain, M. (2017). Apathy in Alzheimer's disease. Current Opinion in Behavioral Sciences, 22, 7–13.

MLA Style

Nobis, L., and M. Husain. “Apathy in Alzheimer's Disease.” Current Opinion in Behavioral Sciences, vol. 22, Elsevier, 2017, pp. 7–13.

Chicago Style

Nobis, L, and M Husain. 2017. “Apathy in Alzheimer's Disease.” Current Opinion in Behavioral Sciences 22: 7–13.
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Files:: Nobis+and+Husain+Apathy+in+AD.pdf

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Publisher copy:: 10.1016/j.cobeha.2017.12.007

Authors

+ Nobis, L More by this author

Institution:: University of Oxford
Division:: Medical Sciences Division
Oxford college:: Wolfson College
Role:: Author

+ Husain, M More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Experimental Psychology
Role:: Author

+ National Institute of Health Research More from this funder

+ Wellcome Trust More from this funder

Publisher:: Elsevier
Journal:: Current Opinion in Behavioral Sciences More from this journal
Volume:: 22
Pages:: 7-13
Publication date:: 2017-12-27
Acceptance date:: 2017-12-13
DOI:: 10.1016/j.cobeha.2017.12.007
ISSN:: 2352-1546

Keywords:: Review

Journal
Pubs id:: pubs:813461
UUID:: uuid:6b54a6bc-924a-4806-a222-449ecd4a328f
Local pid:: pubs:813461
Source identifiers:: 813461
Deposit date:: 2018-01-23

Terms of use

Copyright holder:: © 2017 Nobis and Husain Published by Elsevier Ltd
Copyright date:: 2017
Notes:: This is an Open Access article published under a Creative Commons licence, see: https://creativecommons.org/licenses/by/4.0/

Licence:: CC Attribution (CC BY)

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