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The Val66Met coding variant of the brain-derived neurotrophic factor (BDNF) gene does not contribute toward variation in the personality trait neuroticism.

Abstract:

BACKGROUND: The val66met variant located within the brain-derived neurotrophic factor gene (BDNF) has previously been associated with human neuroticism, a dimension of personality strongly predictive of depressive illness. METHODS: Here we report an attempt to replicate this association using three populations of extreme neuroticism scorers derived from two large English cohorts (n = 88,142 and n = 20,921). On the basis of the current literature, which indicates that an effect of BDNF may on...

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Publication status:
Published

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Journal:
Biological psychiatry More from this journal
Volume:
58
Issue:
9
Pages:
738-742
Publication date:
2005-11-01
DOI:
EISSN:
1873-2402
ISSN:
0006-3223

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