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Cytokine expression and networks in rheumatoid arthritis: rationale for anti-TNF alpha antibody therapy and its mechanism of action.

Abstract:

The cloning of cytokine cDNAs has permitted the analysis of cytokine expression in diseased sites such as rheumatoid joints. A very wide range of cytokines were detected, mostly with proinflammatory activities. From the analysis of cytokine regulation in rheumatoid joint cell cultures using neutralizing anti-cytokine antibodies, it was found that blockade of TNF alpha reduced the production of other proinflammatory cytokines. Hence TNF alpha was a potential therapeutic target. This concept wa...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Journal of inflammation More from this journal
Volume:
47
Issue:
1-2
Pages:
90-96
Publication date:
1995-01-01
ISSN:
1078-7852
Language:
English
Keywords:
Pubs id:
pubs:481648
UUID:
uuid:6b51b625-7e50-408b-8d03-74362c15eb12
Local pid:
pubs:481648
Source identifiers:
481648
Deposit date:
2014-08-29

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