Journal article
Cytokine expression and networks in rheumatoid arthritis: rationale for anti-TNF alpha antibody therapy and its mechanism of action.
- Abstract:
-
The cloning of cytokine cDNAs has permitted the analysis of cytokine expression in diseased sites such as rheumatoid joints. A very wide range of cytokines were detected, mostly with proinflammatory activities. From the analysis of cytokine regulation in rheumatoid joint cell cultures using neutralizing anti-cytokine antibodies, it was found that blockade of TNF alpha reduced the production of other proinflammatory cytokines. Hence TNF alpha was a potential therapeutic target. This concept wa...
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- Publication status:
- Published
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Bibliographic Details
- Journal:
- Journal of inflammation
- Volume:
- 47
- Issue:
- 1-2
- Pages:
- 90-96
- Publication date:
- 1995-01-01
- ISSN:
-
1078-7852
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:481648
- UUID:
-
uuid:6b51b625-7e50-408b-8d03-74362c15eb12
- Local pid:
- pubs:481648
- Source identifiers:
-
481648
- Deposit date:
- 2014-08-29
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- Copyright date:
- 1995
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