Cognitive behavioural therapy as an adjunct to pharmacotherapy for primary care based patients with treatment resistant depression: results of the CoBalT randomised controlled trial.

Journal article

BACKGROUND: Only a third of patients with depression respond fully to antidepressant medication but little evidence exists regarding the best next-step treatment for those whose symptoms are treatment resistant. The CoBalT trial aimed to examine the effectiveness of cognitive behavioural therapy (CBT) as an adjunct to usual care (including pharmacotherapy) for primary care patients with treatment resistant depression compared with usual care alone. METHODS: This two parallel-group multicentr...

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Authors: Wiles, N; Thomas, L; Abel, A; Ridgway, N; Turner, N

• Journal: Lancet
• Volume: 381
• Issue: 9864
• Pages: 375-384
• Publication date: 2013-02-01
• DOI: 10.1016/s0140-6736(12)61552-9
• EISSN: 1474-547X
• ISSN: 0140-6736
• Language: English
• Keywords: Primary Health Care; Middle Aged; Depressive Disorder, Treatment-Resistant; Humans; Adult; Combined Modality Therapy; Male; Female; Cognitive Therapy; Treatment Outcome; Antidepressive Agents