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The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial.

Abstract:

BACKGROUND: Lowering LDL cholesterol with statin regimens reduces the risk of myocardial infarction, ischaemic stroke, and the need for coronary revascularisation in people without kidney disease, but its effects in people with moderate-to-severe kidney disease are uncertain. The SHARP trial aimed to assess the efficacy and safety of the combination of simvastatin plus ezetimibe in such patients. METHODS: This randomised double-blind trial included 9270 patients with chronic kidney disease (3...

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Publication status:
Published

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Authors


Baigent, C More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Trial Service Unit, BHF Centre of Research Excellence
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Trial Service Unit, BHF Centre of Research Excellence
Wheeler, DC More by this author
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Journal:
Lancet
Volume:
377
Issue:
9784
Pages:
2181-2192
Publication date:
2011-06-05
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
URN:
uuid:6b4f9eee-714d-4143-87d9-cedebb190d23
Source identifiers:
166703
Local pid:
pubs:166703

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