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Journal article

Embracing the complexity of RNA regulatory networks: layer by layer.

Abstract:

The alternative splicing (AS) of precursor mRNA is tightly regulated and serves to generate a vast repertoire of RNA and protein variants and to enable expression in a cell-specific manner1. Furthermore, AS profoundly expands the functional capacity of the genome by impacting other regulatory layers, including mRNA transcription, turnover, transport, and translation. Equally, factors regulating chromatin and transcription complexes influence AS. This extensive crosstalk dictates the need to d...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1093/cvr/cvx085

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Oxford college:
All Souls College
Publisher:
Oxford University Press Publisher's website
Journal:
Cardiovascular Research Journal website
Volume:
113
Issue:
8
Pages:
e22-e23
Publication date:
2017-06-22
DOI:
EISSN:
1755-3245
ISSN:
0008-6363
Pubs id:
pubs:708815
URN:
uri:6b4d0ab4-6061-41ed-bd21-cf73974d1e9e
UUID:
uuid:6b4d0ab4-6061-41ed-bd21-cf73974d1e9e
Local pid:
pubs:708815
Language:
English
Keywords:

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