Embracing the complexity of RNA regulatory networks: layer by layer.
The alternative splicing (AS) of precursor mRNA is tightly regulated and serves to generate a vast repertoire of RNA and protein variants and to enable expression in a cell-specific manner1. Furthermore, AS profoundly expands the functional capacity of the genome by impacting other regulatory layers, including mRNA transcription, turnover, transport, and translation. Equally, factors regulating chromatin and transcription complexes influence AS. This extensive crosstalk dictates the need to d...Expand abstract
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- Smart, N
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