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Quantification of oncogene dosage in tumours by simultaneous dual-label hybridization.

Abstract:

Gene amplification and allele loss occur in a variety of human tumours and some have prognostic value. Therefore, techniques which facilitate detection and quantification of gene dosage could have wide applicability in cancer research. Using the INT-2 gene as a model system, a quantitative procedure has been developed for measuring gene copy number using dual-label hybridization to DNA dot blots. A probe specific for the INT-2 gene was labelled with [alpha-32P]dCTP and a probe to beta-actin, ...

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Journal:
Oncogene More from this journal
Volume:
8
Issue:
1
Pages:
223-227
Publication date:
1993-01-01
EISSN:
1476-5594
ISSN:
0950-9232
Language:
English
Keywords:
Pubs id:
pubs:72300
UUID:
uuid:6b4c0140-08af-40a7-8622-76924100a815
Local pid:
pubs:72300
Source identifiers:
72300
Deposit date:
2012-12-19

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