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High-speed single-particle tracking of GM1 in model membranes reveals anomalous diffusion due to interleaflet coupling and molecular pinning.

Abstract:

The biological functions of the cell membrane are influenced by the mobility of its constituents, which are thought to be strongly affected by nanoscale structure and organization. Interactions with the actin cytoskeleton have been proposed as a potential mechanism with the control of mobility imparted through transmembrane "pickets" or GPI-anchored lipid nanodomains. This hypothesis is based on observations of molecular mobility using various methods, although many of these lack the spatiote...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1021/nl502536u

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Institution:
University of Oxford
Department:
Molecular Medicine
Role:
Author
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Publisher:
American Chemical Society Publisher's website
Journal:
Nano letters Journal website
Volume:
14
Issue:
9
Pages:
5390-5397
Publication date:
2014-01-01
DOI:
EISSN:
1530-6992
ISSN:
1530-6984
Source identifiers:
481509
Language:
English
Keywords:
Pubs id:
pubs:481509
UUID:
uuid:6b471a07-1451-48f1-bba2-18f68d49fb2f
Local pid:
pubs:481509
Deposit date:
2014-09-21

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