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Large scale meta-analysis identifies new genetic risk loci for esophageal adenocarcinoma (EA) and the first EA risk locus independent of Barrett’s esophagus

Abstract:

Esophageal adenocarcinoma (EA) is an often fatal cancer with rising incidence in the developed world. Barrett’s esophagus (BE) is a pre-cancerous metaplastic precursor of EA. We performed the first genome-wide association study (GWAS) meta-analysis for BE and EA to date, using 6,167 BE cases, 4,112 EA cases, and 17,159 unscreened controls, all of European descent. We identified eight new genome-wide significant associated (P<5×10-8) risk loci for BE and/or EA within or near CFTR, MSRA, ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/S1470-2045(16)30240-6

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Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
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Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
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Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
Gharahkhani, P More by this author
MacGregor, S More by this author
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Australian Research Council More from this funder
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Publisher:
Elsevier Publisher's website
Journal:
Lancet Oncology Journal website
Volume:
17
Issue:
10
Pages:
p1363–1373
Publication date:
2016-06-05
Acceptance date:
2016-06-07
DOI:
ISSN:
1474-5488
Pubs id:
pubs:633476
URN:
uri:6b429903-9518-452f-b3ea-402aa56301a3
UUID:
6b429903-9518-452f-b3ea-402aa56301a3
Local pid:
pubs:633476

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