Imaging Cardiac Developmental Malformations in the Mouse Embryo

Journal article

This chapter discusses imaging cardiac developmental malfunctions in the mouse embryo. Studies of human genetic architecture cannot provide a mechanistic understanding of gene function in cardiac development, and analysis of gene-gene and gene-environment interactions in humans remains a challenge. These considerations necessitate the use of animal models, the most appropriate and widely used being the mouse. Like the human, the mouse has a four-chambered heart with a septated outflow tract, ...

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Authors: Mohun, T; Weninger, W; Bhattacharya, S

• Publisher: Elsevier
• Pages: 779-791
• Publication date: 2010-01-01
• DOI: 10.1016/B978-0-12-381332-9.00036-0
• Language: English