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Journal article

HIVconsv vaccines and romidepsin in early-treated HIV-1-infected individuals: Safety, immunogenicity and effect on the viral reservoir (Study BCN02)

Abstract:

Kick&kill strategies combining drugs aiming to reactivate the viral reservoir with therapeutic vaccines to induce effective cytotoxic immune responses hold potential to achieve a functional cure for HIV-1 infection. Here, we report on an open-label, single-arm, phase I clinical trial, enrolling 15 early-treated HIV-1-infected individuals, testing the combination of the histone deacetylase inhibitor romidepsin as a latency-reversing agent and the MVA.HIVconsv vaccine. Romidepsin treatment resu...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.3389/fimmu.2020.00823

Authors


More from this funder
Name:
European Commission
Grant:
681137
SRIA-2015-1066
More from this funder
Name:
Medical Research Council
Grant:
MR/N023668/1
G0701669
G1001757
Publisher:
Frontiers Media
Journal:
Frontiers in Immunology More from this journal
Volume:
11
Article number:
823
Publication date:
2020-05-06
Acceptance date:
2020-04-09
DOI:
EISSN:
1664-3224
Pmid:
32435247
Language:
English
Keywords:
Pubs id:
1106304
Local pid:
pubs:1106304
Deposit date:
2020-06-02

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