Development of a robust nanoscaffold as a modular vaccine platform

Thesis

Protein nanoparticles have been used as platforms to multimerize and present otherwise weakly immunogenic antigens to the immune system. Virus-like particles (VLPs) are self-assembling protein cages, forming the basis of safe and immunogenic vaccines that have been administered to millions of people. However, the creation of chimeric VLPs that display heterologous antigens through either genetic fusion or chemical coupling continues to be a challenge. To address this challenge, a modular v...

Expand abstract

Authors: Bruun, T

• Type of award: MSc by Research
• Level of award: Masters
• Awarding institution: University of Oxford
• Language: English
• Keywords: Vaccines
• Subjects: Nanoparticles