IA-2 antibody prevalence and risk assessment of early insulin requirement in subjects presenting with type 2 diabetes (UKPDS 71).

Journal article

AIMS/HYPOTHESIS: Established autoimmune markers of type 1 diabetes, including islet cell autoantibodies (ICA) and autoantibodies to glutamic acid decarboxylase (GADA) have been used to screen people presenting with type 2 diabetes for latent autoimmune diabetes in adults. We have examined the prevalence of autoantibodies to protein tyrosine phosphatase isoforms IA-2 (IA-2A) and IA-2beta/phogrin (IA-2betaA) in a cohort of adult UKPDS patients thought to have type 2 diabetes, and investigated t...

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Authors: Bottazzo, G; Bosi, E; Cull, C; Bonifacio, E; Locatelli, M

• Publication status: Published
• Journal: Diabetologia
• Volume: 48
• Issue: 4
• Pages: 703-708
• Publication date: 2005-04-01
• DOI: 10.1007/s00125-005-1691-9
• EISSN: 1432-0428
• ISSN: 0012-186X
• Language: English
• Keywords: Protein Tyrosine Phosphatases; Female; Prospective Studies; Adult; Glutamate Decarboxylase; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Humans; Diabetes Mellitus, Type 2; Aged; Receptor-Like Protein Tyrosine Phosphatases, Class 8; HLA-DR Antigens; Age Factors; Multivariate Analysis; Autoantibodies; Prevalence; Insulin; Logistic Models; Middle Aged; Risk Assessment; Membrane Proteins; Male