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Flagellar morphogenesis: protein targeting and assembly in the paraflagellar rod of trypanosomes.

Abstract:

The paraflagellar rod (PFR) of the African trypanosome Trypanosoma brucei represents an excellent model to study flagellum assembly. The PFR is an intraflagellar structure present alongside the axoneme and is composed of two major proteins, PFRA and PFRC. By inducible expression of a functional epitope-tagged PFRA protein, we have been able to monitor PFR assembly in vivo. As T. brucei cells progress through their cell cycle, they possess both an old and a new flagellum. The induction of expr...

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Publication status:
Published

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Authors


MacRae, TH More by this author
Francis, SB More by this author
Matthews, KR More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Molecular and cellular biology
Volume:
19
Issue:
12
Pages:
8191-8200
Publication date:
1999-12-05
EISSN:
1098-5549
ISSN:
0270-7306
URN:
uuid:6b38fa86-c738-4f54-8fc6-af548cd1cd09
Source identifiers:
19549
Local pid:
pubs:19549

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