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U.K. controlled trial of intrapleural streptokinase for pleural infection

Abstract:

BACKGROUND: Intrapleural fibrinolytic agents are used in the drainage of infected pleural-fluid collections. This use is based on small trials that did not have the statistical power to evaluate accurately important clinical outcomes, including safety. We conducted a trial to clarify the therapeutic role of intrapleural streptokinase. METHODS: In this double-blind trial, 454 patients with pleural infection (defined by the presence of purulent pleural fluid or pleural fluid with a pH below 7.2...

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Publisher copy:
10.1056/NEJMoa042473

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Journal:
New England Journal of Medicine More from this journal
Volume:
352
Issue:
9
Pages:
865-874
Publication date:
2005-03-03
DOI:
ISSN:
0028-4793
Language:
English
Pubs id:
pubs:80049
UUID:
uuid:6b33aa91-e829-4552-b7cc-0d228e051a5c
Local pid:
pubs:80049
Source identifiers:
80049
Deposit date:
2012-12-19

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