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Identification of a novel proinsulin-associated SNP and demonstration that proinsulin is unlikely to be a causal factor in subclinical vascular remodelling using Mendelian randomisation

Abstract:

Increased proinsulin relative to insulin levels have been associated with subclinical atherosclerosis (measured by carotid intima-media thickness (cIMT)) and are predictive of future cardiovascular disease (CVD), independently of established risk factors. The mechanisms linking proinsulin to atherosclerosis and CVD are unclear. A genome-wide meta-analysis has identified nine loci associated with circulating proinsulin levels. Using proinsulin-associated SNPs, we set out to use a Mendelian ran...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.atherosclerosis.2017.09.031

Authors


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Name:
Italian Ministry of Health
Publisher:
Elsevier
Journal:
Atherosclerosis More from this journal
Volume:
266
Pages:
196-204
Publication date:
2017-09-28
Acceptance date:
2017-09-27
DOI:
EISSN:
1879-1484
ISSN:
0021-9150
Pmid:
29040868
Language:
English
Keywords:
Pubs id:
pubs:737221
UUID:
uuid:6b30bc30-f892-48e9-bbd3-ec70eee0ade3
Local pid:
pubs:737221
Source identifiers:
737221
Deposit date:
2017-11-27

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