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Journal article

Identification of a novel proinsulin-associated SNP and demonstration that proinsulin is unlikely to be a causal factor in subclinical vascular remodelling using Mendelian randomisation

Abstract:

Increased proinsulin relative to insulin levels have been associated with subclinical atherosclerosis (measured by carotid intima-media thickness (cIMT)) and are predictive of future cardiovascular disease (CVD), independently of established risk factors. The mechanisms linking proinsulin to atherosclerosis and CVD are unclear. A genome-wide meta-analysis has identified nine loci associated with circulating proinsulin levels. Using proinsulin-associated SNPs, we set out to use a Mendelian ran...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.atherosclerosis.2017.09.031

Authors


Strawbridge, RJ More by this author
Silveira, A More by this author
Gustafsson, S More by this author
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European Commission More from this funder
Swedish Heart-Lung Foundation More from this funder
Swedish Research Council More from this funder
Knut and Alice Wallenberg Foundation More from this funder
Foundation for Strategic Research More from this funder
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Publisher:
Elsevier Publisher's website
Journal:
Atherosclerosis Journal website
Volume:
266
Pages:
196-204
Publication date:
2017-09-28
Acceptance date:
2017-09-27
DOI:
EISSN:
1879-1484
ISSN:
0021-9150
Pubs id:
pubs:737221
URN:
uri:6b30bc30-f892-48e9-bbd3-ec70eee0ade3
UUID:
uuid:6b30bc30-f892-48e9-bbd3-ec70eee0ade3
Local pid:
pubs:737221

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