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Immunisation with BCG and recombinant MVA85A induces long-lasting, polyfunctional Mycobacterium tuberculosis-specific CD4+ memory T lymphocyte populations.

Abstract:

In the search for effective vaccines against intracellular pathogens such as HIV, tuberculosis and malaria, recombinant viral vectors are increasingly being used to boost previously primed T cell responses. Published data have shown prime-boost vaccination with BCG-MVA85A (modified vaccinia virus Ankara expressing antigen 85A) to be highly immunogenic in humans as measured by ex vivo IFN-gamma ELISPOT. Here, we used polychromatic flow cytometry to investigate the phenotypic and functional pro...

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Publication status:
Published

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Publisher copy:
10.1002/eji.200737504

Authors


Beveridge, NE More by this author
Casazza, JP More by this author
Pathan, AA More by this author
Sander, CR More by this author
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Journal:
European journal of immunology
Volume:
37
Issue:
11
Pages:
3089-3100
Publication date:
2007-11-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:6b2eebbd-762b-47fb-883c-1edd7b7e46bc
Source identifiers:
40595
Local pid:
pubs:40595

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