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Genetic control of differential acetylation in diabetic rats

Abstract:

Post-translational protein modifications such as acetylation have significant regulatory roles in metabolic processes, but their relationship to both variation in gene expression and DNA sequence is unclear. We address this question in the Goto-Kakizaki (GK) rat inbred strain, a model of polygenic type 2 diabetes. Expression of the NAD-dependent deacetylase Sirtuin-3 is down-regulated in GK rats compared to normoglycemic Brown Norway (BN) rats. We show first that a promoter SNP causes down-re...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0094555

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Role:
Author
Publisher:
Public Library of Science
Journal:
PLoS ONE More from this journal
Volume:
9
Issue:
4
Pages:
ARTN e94555
Publication date:
2014-04-17
Acceptance date:
2014-03-18
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Language:
English
Keywords:
UUID:
uuid:6b2e976d-0c52-4968-86b1-cd90ec2b44da
Local pid:
pubs:462384
Source identifiers:
462384
Deposit date:
2014-05-10

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