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A randomized pilot study of L-arginine infusion in severe falciparum malaria: preliminary safety, efficacy and pharmacokinetics

Abstract:

Background Decreased nitric oxide (NO) and hypoargininemia are associated with severe falciparum malaria and may contribute to severe disease. Intravenous L-arginine increases endothelial NO in moderately-severe malaria (MSM) without adverse effects. The safety, efficacy and pharmacokinetics of L-arginine or other agents to improve NO bioavailability in severe malaria have not been assessed. Methods In an open-label pilot study of L-arginine in adults with severe malaria (ARGISM-1 Study), pat...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0069587

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Publisher:
Public Library of Science
Journal:
PLoS ONE More from this journal
Volume:
8
Issue:
7
Pages:
ARTN e69587
Publication date:
2013-07-29
Acceptance date:
2013-06-10
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Language:
English
Keywords:
UUID:
uuid:6b2924b6-1323-425c-a855-c69d297622bf
Local pid:
pubs:416564
Source identifiers:
416564
Deposit date:
2013-11-16

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