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Journal article

The complexity of genetic variation in a simple immune system.

Abstract:
Fruitflies derived from a wild population vary in their resistance to infection with the bacterial pathogen Serratia marcescens. A survey of nucleotide diversity in 21 genes involved in innate immunity concluded that 16 genes had polymorphisms associated with resistance to this specific pathogen. However, the effects of individual polymorphisms on the resistance phenotype were modest, and epistatic interactions appeared to be common. What might these findings tell us about genetic resistance to infection in humans?
Publication status:
Published

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Publisher copy:
10.1016/j.tig.2005.02.002

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
Journal:
Trends in genetics : TIG More from this journal
Volume:
21
Issue:
4
Pages:
197-199
Publication date:
2005-04-01
DOI:
ISSN:
0168-9525
Language:
English
Keywords:
Pubs id:
pubs:33044
UUID:
uuid:6b22c199-fc6f-4850-a85a-b8812a49d48b
Local pid:
pubs:33044
Source identifiers:
33044
Deposit date:
2012-12-19

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