Journal article
TNFα signalling primes chromatin for NF-κB binding and induces rapid and widespread nucleosome repositioning.
- Abstract:
-
The rearrangement of nucleosomes along the DNA fiber profoundly affects gene expression, but little is known about how signalling reshapes the chromatin landscape, in three-dimensional space and over time, to allow establishment of new transcriptional programs.Using micrococcal nuclease treatment and high-throughput sequencing, we map genome-wide changes in nucleosome positioning in primary human endothelial cells stimulated with tumour necrosis factor alpha (TNFα) - a proinflammatory cytokin...
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- Publication status:
- Published online
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- Publisher copy:
- 10.1186/s13059-014-0536-6
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Bibliographic Details
- Journal:
- Genome biology
- Volume:
- 15
- Issue:
- 12
- Pages:
- 536
- Chapter number:
- ARTN 536
- Publication date:
- 2014-01-05
- DOI:
- EISSN:
-
1474-760X
- ISSN:
-
1474-7596
- URN:
-
uuid:6b1e02ed-db4f-43fc-aa68-44e880e81dab
- Source identifiers:
-
503555
- Local pid:
- pubs:503555
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright date:
- 2014
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