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TNFα signalling primes chromatin for NF-κB binding and induces rapid and widespread nucleosome repositioning.

Abstract:

The rearrangement of nucleosomes along the DNA fiber profoundly affects gene expression, but little is known about how signalling reshapes the chromatin landscape, in three-dimensional space and over time, to allow establishment of new transcriptional programs.Using micrococcal nuclease treatment and high-throughput sequencing, we map genome-wide changes in nucleosome positioning in primary human endothelial cells stimulated with tumour necrosis factor alpha (TNFα) - a proinflammatory cytokin...

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Publication status:
Published online

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Publisher copy:
10.1186/s13059-014-0536-6

Authors


Diermeier, S More by this author
Kolovos, P More by this author
Heizinger, L More by this author
Schwartz, U More by this author
Georgomanolis, T More by this author
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Journal:
Genome biology
Volume:
15
Issue:
12
Pages:
536
Publication date:
2014-01-05
DOI:
EISSN:
1474-760X
ISSN:
1474-7596
URN:
uuid:6b1e02ed-db4f-43fc-aa68-44e880e81dab
Source identifiers:
503555
Local pid:
pubs:503555

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