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Association of IL-10-promoter genetic variants with the rate of CD4 T-cell loss, IL-10 plasma levels, and breadth of cytotoxic T-cell lymphocyte response during chronic HIV-1 infection.

Abstract:

BACKGROUND: Interleukin-10 (IL-10) is a potent immunoregulatory cytokine. IL-10-promoter polymorphisms have been shown to affect human immunodeficiency virus type 1 (HIV-1) clinical outcomes but the underlying mechanisms are poorly understood. METHODS: We investigated the relationship between IL-10-promoter variants, plasma cytokine levels, immune responses and markers of disease outcome in antiretroviral-naïve HIV-1 chronically infected individuals from South Africa. Two IL-10-promoter sing...

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Publisher copy:
10.1093/cid/cir811

Authors


Journal:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America More from this journal
Volume:
54
Issue:
2
Pages:
294-302
Publication date:
2012-01-01
DOI:
EISSN:
1537-6591
ISSN:
1058-4838
Language:
English
Keywords:
Pubs id:
pubs:239847
UUID:
uuid:6b179802-6fe2-4b78-8f6b-1a73f7c09ed5
Local pid:
pubs:239847
Source identifiers:
239847
Deposit date:
2012-12-19

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