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The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity.

Abstract:

There are three prolyl hydroxylases (PHD1, 2 and 3) that regulate the hypoxia-inducible factors (HIFs), the master transcriptional regulators that respond to changes in intracellular O(2) tension. In high O(2) tension (normoxia) the PHDs hydroxylate two conserved proline residues on HIF-1α, which leads to binding of the von Hippel-Lindau (VHL) tumour suppressor, the recognition component of a ubiquitin-ligase complex, initiating HIF-1α ubiquitylation and degradation. However, it is not known ...

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Publication status:
Published

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Publisher copy:
10.1038/ncb2424

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Journal:
Nature cell biology More from this journal
Volume:
14
Issue:
2
Pages:
201-208
Publication date:
2012-02-01
DOI:
EISSN:
1476-4679
ISSN:
1465-7392

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