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Isolation and characterization of monoclonal antibodies raised against the reverse transcriptase of human immunodeficiency virus type 2 and cross-reactivity with that of type 1.

Abstract:

Monoclonal antibodies to human immunodeficiency virus (HIV)-2 reverse transcriptase have been raised with the ultimate goal of generating Fab fragments for future co-crystallization studies. A number of mouse monoclonal antibodies to recombinant HIV-2 reverse transcriptase have been obtained and characterized in terms of the possible epitopes they recognise together with cross-reactivity with a related reverse transcriptase. The antibodies were shown to fall into three groups that recognize d...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
Role:
Author
Journal:
Journal of acquired immune deficiency syndromes
Volume:
6
Issue:
11
Pages:
1187-1193
Publication date:
1993-11-05
ISSN:
0894-9255
URN:
uuid:6b0b656b-265d-4b76-8ab0-cdcc3e07a673
Source identifiers:
72676
Local pid:
pubs:72676

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