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A kit formulated under good manufacturing practices for labeling human epidermal growth factor with 111In for radiotherapeutic applications.

Abstract:

UNLABELLED: Our goal was to design and manufacture a kit under good manufacturing practices (GMP) for the preparation of (111)In-DTPA-hEGF Injection, a novel targeted radiotherapeutic agent for advanced epidermal growth factor receptor (EGFR)-positive breast cancer. METHODS: Human EGF (hEGF) was derivatized with diethylenetriaminepentaacetic acid (DTPA) and then purified by size-exclusion chromatography and ultrafiltration. Kits were prepared by dispensing 0.25 mg (1 mL) of DTPA-hEGF in 1 mo...

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Publication status:
Published

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Authors


Reilly, RM More by this author
Scollard, DA More by this author
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Journal:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Volume:
45
Issue:
4
Pages:
701-708
Publication date:
2004-04-05
EISSN:
1535-5667
ISSN:
0161-5505
URN:
uuid:6b080890-04a5-49b0-bd6d-750e528c0f35
Source identifiers:
131319
Local pid:
pubs:131319

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