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Thesis

HSV-1 amplicon system for human artificial chromosome formation in human ES/iPS cells and pluripotency induction

Abstract:

Development of safe and efficient approaches for gene delivery in human embryonic stem cells (hESc) and particularly in human induced pluripotent stem (hiPS) cells, which can be derived in a person-specific manner, is considered to be imperative for harnessing their full potential in both the basic and applied research. The aim of this study was to evaluate the potential of human artificial chromosome (HAC) for gene delivery and expression in hESc and hiPS cells. HAC offers many potential ...

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Institution:
University of Oxford
Oxford college:
Keble College
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of

Contributors

Role:
Supervisor
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
URN:
uuid:6b04170b-f2d9-4114-9511-05a1a98ccfec
Local pid:
ora:7508

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