- Abstract:
-
The potent and selective non-peptide cholecystokinin (CCK) antagonist L-364,718 (0.5-2.0 mg/kg s.c.) enhanced the analgesia induced by acute morphine treatment in the rat tail flick test. Chronic treatment with L-364,718 (1.0 mg/kg) prevented the development of tolerance to morphine analgesia (after a 6 day period of morphine treatment) but did not influence the onset of opioid dependence. Since L-364,718 is considerably more potent in inhibiting CCK binding to peripheral tissues than to brai...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/0014-2999(88)90183-5
-
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- Journal:
- European journal of pharmacology
- Volume:
- 147
- Issue:
- 3
- Pages:
- 469-472
- Publication date:
- 1988-03-05
- DOI:
- EISSN:
-
1879-0712
- ISSN:
-
0014-2999
- URN:
-
uuid:6b016ce8-b959-45b9-8177-3f896e155c6c
- Source identifiers:
-
15588
- Local pid:
- pubs:15588
- Language:
- English
- Keywords:
- Copyright date:
- 1988
Journal article
Enhancement of morphine analgesia and prevention of morphine tolerance in the rat by the cholecystokinin antagonist L-364,718.
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