Journal article icon

Journal article

Enhancement of morphine analgesia and prevention of morphine tolerance in the rat by the cholecystokinin antagonist L-364,718.

Abstract:

The potent and selective non-peptide cholecystokinin (CCK) antagonist L-364,718 (0.5-2.0 mg/kg s.c.) enhanced the analgesia induced by acute morphine treatment in the rat tail flick test. Chronic treatment with L-364,718 (1.0 mg/kg) prevented the development of tolerance to morphine analgesia (after a 6 day period of morphine treatment) but did not influence the onset of opioid dependence. Since L-364,718 is considerably more potent in inhibiting CCK binding to peripheral tissues than to brai...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Dourish, CT More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Journal:
European journal of pharmacology
Volume:
147
Issue:
3
Pages:
469-472
Publication date:
1988-03-05
DOI:
EISSN:
1879-0712
ISSN:
0014-2999
URN:
uuid:6b016ce8-b959-45b9-8177-3f896e155c6c
Source identifiers:
15588
Local pid:
pubs:15588

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP