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Controlling the frontier: regulatory T-cells and intestinal homeostasis.

Abstract:

The intestine represents one of the most challenging sites for the immune system as immune cells must be able to mount an efficient response to invading pathogens while tolerating the large number and diverse array of resident commensal bacteria. Foxp3(+) regulatory T-cells (Tregs) play a non-redundant role at maintaining this balance. At the same time Treg cell differentiation and function can be modulated by the intestinal microbiota. In this review, we will discuss effector mechanisms of T...

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Publication status:
Published

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Publisher copy:
10.1016/j.smim.2013.09.002

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Journal:
Seminars in immunology
Volume:
25
Issue:
5
Pages:
352-357
Publication date:
2013-11-01
DOI:
EISSN:
1096-3618
ISSN:
1044-5323
Source identifiers:
438787
Language:
English
Keywords:
Pubs id:
pubs:438787
UUID:
uuid:6afaa9b6-9473-4b27-a524-c6234c0387a9
Local pid:
pubs:438787
Deposit date:
2014-02-08

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