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Hand Osteoarthritis: investigating Pain Effects of estrogen-containing therapy (HOPE-e): a protocol for a feasibility randomised placebo-controlled trial

Abstract:

Background: Hand osteoarthritis (OA) is a common condition, causing pain, stiffness and reduced quality of life. Incidence is higher amongst women, particularly around the age of the menopause. Whilst the relationship between sex hormones and OA has been studied in vitro, in epidemiological studies and in clinical trials of hormone replacement therapy (HRT), this study is the first to investigate the effect of estrogen-containing therapy on hand pain in post-menopausal wo... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s40814-021-00869-1

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Centre for Statistics in Medicine
Role:
Author
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Publisher:
BioMed Central Publisher's website
Journal:
Pilot and Feasibility Studies Journal website
Volume:
7
Article number:
133
Publication date:
2021-06-24
Acceptance date:
2021-06-07
DOI:
ISSN:
2055-5784
Language:
English
Keywords:
Pubs id:
1182615
Local pid:
pubs:1182615
Deposit date:
2021-06-18

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