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Thesis

Metabolomics in hypertrophic cardiomyopathy and other myocardial diseases

Abstract:

Despite the clinical importance of hypertrophic cardiomyopathy (HCM) and a recognition that aberrant energetics contributes to its pathogenesis, significant uncertainty remains regarding the determinants of the clinical phenotype. The central hypothesis underlying this thesis is that the clinical manifestations of HCM are causatively influenced by perturbations in cellular metabolism, and that the metabolome in HCM, both at rest and during stress, is distinct from that of healthy hearts an...

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Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author

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Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:6af4444d-d067-4032-b1ad-b151bd2df5a6
Deposit date:
2017-12-05

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