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The path of RNA through nuclear pores: apparent entry from the sides into specialized pores.

Abstract:

The path that RNA takes through nuclear pores was mapped using two high-resolution techniques. Unexpectedly, no RNA in HL60 cells was detected by immunogold labelling in the central axis of the pore complex on its way to the transporter at the nuclear membrane; instead, it was distributed around the sides, apparently entering just before the membrane. In rat liver nuclei, poly(A)(+) RNA, hnRNPs A1 and C, mrnp 41, ASF, and a phosphorylated subset of SR proteins were also distributed like mRNA,...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Journal of cell science
Volume:
113 Pt 2
Issue:
2
Pages:
291-302
Publication date:
2000-01-05
EISSN:
1477-9137
ISSN:
0021-9533
URN:
uuid:6af1a703-ea18-4a03-8981-9fd85267e64b
Source identifiers:
28844
Local pid:
pubs:28844

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