Journal article
Quantification of CD4(+) T cell alloreactivity and its control by regulatory T cells using time lapse microscopy and immune synapse detection.
- Abstract:
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Assays designed to select transplant recipients for immunosuppression withdrawal have met with limited success, perhaps because they measure events downstream of T cell-alloantigen interactions. Using in vitro time lapse microscopy in a mouse transplant model we asked whether transplant outcome would result in changes in the proportion of CD4(+) T cells forming prolonged interactions with donor dendritic cells. By blocking CD4-MHC class II and CD28-B7 interactions, we defined immunologically ...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Version of record, pdf, 1016.6KB)
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- Publisher copy:
- 10.1111/ajt.13607
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Authors
Funding
+ Kidney Research UK
More from this funder
Funding agency for:
Hester, J
Grant:
Senior Non-Clinical Fellowship
Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons Journal website
- Pages:
- n/a-n/a
- Publication date:
- 2015-01-01
- DOI:
- EISSN:
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1600-6143
- ISSN:
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1600-6135
- Source identifiers:
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585899
Item Description
- Language:
- English
- Pubs id:
-
pubs:585899
- UUID:
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uuid:6aec50c9-ee1d-402b-97c1-121ecea30e57
- Local pid:
- pubs:585899
- Deposit date:
- 2016-02-01
Terms of use
- Copyright holder:
- Juvet et al
- Copyright date:
- 2015
- Notes:
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Copyright © 2015 The Authors. American Journal of Transplantation published by Wiley Periodicals, Inc. on behalf of American Society of Transplant Surgeons
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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