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Quantification of CD4(+) T cell alloreactivity and its control by regulatory T cells using time lapse microscopy and immune synapse detection.

Abstract:

Assays designed to select transplant recipients for immunosuppression withdrawal have met with limited success, perhaps because they measure events downstream of T cell-alloantigen interactions. Using in vitro time lapse microscopy in a mouse transplant model we asked whether transplant outcome would result in changes in the proportion of CD4(+) T cells forming prolonged interactions with donor dendritic cells. By blocking CD4-MHC class II and CD28-B7 interactions, we defined immunologically ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1111/ajt.13607

Authors


Sanderson, S More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Bushell, A More by this author
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Funding agency for:
Hester, J
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Grant:
ONE Study; BioDRIM
Publisher:
Wiley Publisher's website
Journal:
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons Journal website
Pages:
n/a-n/a
Publication date:
2015
DOI:
EISSN:
1600-6143
ISSN:
1600-6135
URN:
uuid:6aec50c9-ee1d-402b-97c1-121ecea30e57
Source identifiers:
585899
Local pid:
pubs:585899
Language:
English

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