Journal article

The influence of negative emotions on pain: behavioural effects and neural mechanisms

Abstract:: The idea that pain can lead to feelings of frustration, worry, anxiety and depression seems obvious, particularly if it is of a chronic nature. However, there is also evidence for the reverse causal relationship in which negative mood and emotion can lead to pain or exacerbate it. Here, we review findings from studies on the modulation of pain by experimentally induced mood changes and clinical mood disorders. We discuss possible neural mechanisms underlying this modulatory influence focusing on the periaqueductal grey (PAG), amygdala, anterior cingulate cortex (ACC) and anterior insula as key players in both, pain and affective processing.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Wiech, K., & Tracey, I. (2009). The influence of negative emotions on pain: behavioural effects and neural mechanisms. NeuroImage, 47(3), 987–994.

MLA Style

Wiech, K., and I. Tracey. “The Influence of Negative Emotions on Pain: Behavioural Effects and Neural Mechanisms.” NeuroImage, vol. 47, no. 3, Elsevier, 2009, pp. 987–94.

Chicago Style

Wiech, K, and I Tracey. 2009. “The Influence of Negative Emotions on Pain: Behavioural Effects and Neural Mechanisms.” NeuroImage 47 (3): 987–94.
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Publisher copy:: 10.1016/j.neuroimage.2009.05.059

Authors

+ Wiech, K More by this author

Institution:: University of Oxford
Research group:: Oxford Centre for Functional Magnetic Resonance Imaging of the Brain
Department:: Medical Sciences Division - Clinical Neurology
Role:: Author

+ Tracey, I More by this author

Institution:: University of Oxford
Department:: Medical Sciences Division - Anaesthetics,Nuffield Department of
Role:: Author

Publisher:: Elsevier
Journal:: NeuroImage More from this journal
Volume:: 47
Issue:: 3
Pages:: 987-994
Publication date:: 2009-09-01
DOI:: 10.1016/j.neuroimage.2009.05.059
ISSN:: 10538119

Language:: English
Keywords:: emotions

pain
Subjects:: Anaesthetics

Neuroscience
UUID:: uuid:6ae84294-7cc0-4f07-86ae-77c6fa21fde9
Local pid:: ora:5373
Deposit date:: 2011-05-26

Terms of use

Copyright holder:: Elsevier Inc
Copyright date:: 2009
Notes:: The full-text of this article is not currently available in ORA, but you may be able to access the article via the publisher copy link on this record page.

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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