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Insulin-like growth factor II plays a central role in atherosclerosis in a mouse model.

Abstract:

Insulin-like growth factor II is a fetal promoter of cell proliferation that is involved in some forms of cancer and overgrowth syndromes in humans. Here, we provide two sources of genetic evidence for a novel, pivotal role of locally produced insulin-like growth factor II in the development of atherosclerosis. First, we show that homozygosity for a disrupted insulin-like growth factor II allele in mice lacking apolipoprotein E, a widely used animal model of atherosclerosis, results in aortic...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m108061200

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Journal of biological chemistry More from this journal
Volume:
277
Issue:
6
Pages:
4505-4511
Publication date:
2002-02-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Language:
English
Keywords:
Pubs id:
pubs:458581
UUID:
uuid:6ae4e5ec-74ac-48ef-99c1-ae0afa6677f4
Local pid:
pubs:458581
Source identifiers:
458581
Deposit date:
2014-08-16

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