Journal article
LEAPT: lectin-directed enzyme-activated prodrug therapy.
- Abstract:
-
Targeted drug delivery to selected sites allows reduced toxicity, enhanced efficiency and interchangeable target potential [Langer, R. (2001) Science 293, 58-59 and Molema, G. and Meijer, D. K. F., eds. (2001) Drug Targeting (Wiley-VCH, Weinheim, Germany)]. We describe a bipartite drug-delivery system that exploits (I) endogenous carbohydrate-to-lectin binding to localize glycosylated enzyme conjugates to specific, predetermined cell types followed by (II) administration of a prodrug activate...
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- Publication status:
- Published
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- Publisher copy:
- 10.1073/pnas.0303574101
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Bibliographic Details
- Journal:
- Proceedings of the National Academy of Sciences of the United States of America
- Volume:
- 101
- Issue:
- 40
- Pages:
- 14527-14532
- Publication date:
- 2004-10-01
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- Source identifiers:
-
25229
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:25229
- UUID:
-
uuid:6ae4a3cb-5767-4483-ba4e-dc4f373c4f8f
- Local pid:
- pubs:25229
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2004
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