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Journal article

LEAPT: lectin-directed enzyme-activated prodrug therapy.

Abstract:

Targeted drug delivery to selected sites allows reduced toxicity, enhanced efficiency and interchangeable target potential [Langer, R. (2001) Science 293, 58-59 and Molema, G. and Meijer, D. K. F., eds. (2001) Drug Targeting (Wiley-VCH, Weinheim, Germany)]. We describe a bipartite drug-delivery system that exploits (I) endogenous carbohydrate-to-lectin binding to localize glycosylated enzyme conjugates to specific, predetermined cell types followed by (II) administration of a prodrug activate...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0303574101

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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
101
Issue:
40
Pages:
14527-14532
Publication date:
2004-10-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:6ae4a3cb-5767-4483-ba4e-dc4f373c4f8f
Source identifiers:
25229
Local pid:
pubs:25229

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