Journal article
The transcriptional repressor Blimp1/PRDM1 regulates the maternal decidual response in mice
- Abstract:
-
The transcriptional repressor Blimp1 controls cell fate decisions in the developing embryo and adult tissues. Here we describe Blimp1 expression and functional requirements within maternal uterine tissues during pregnancy. Expression is robustly up-regulated at early post-implantation stages in the primary decidual zone (PDZ) surrounding the embryo. Conditional inactivation results in defective formation of the PDZ barrier and abnormal trophectoderm invasion. RNA-Seq analysis demonstrates dow...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
NICHD NIH HHS
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Bibliographic Details
- Publisher:
- Nature Research Publisher's website
- Journal:
- Nature Communications Journal website
- Volume:
- 11
- Issue:
- 1
- Article number:
- 2782
- Place of publication:
- England
- Publication date:
- 2020-06-03
- Acceptance date:
- 2020-05-11
- DOI:
- EISSN:
-
2041-1723
- Pmid:
-
32493987
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1109584
- Local pid:
- pubs:1109584
- Deposit date:
- 2020-06-29
Terms of use
- Copyright holder:
- Goolam et al.
- Copyright date:
- 2020
- Rights statement:
- © The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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