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The transcriptional repressor Blimp1/PRDM1 regulates the maternal decidual response in mice

Abstract:

The transcriptional repressor Blimp1 controls cell fate decisions in the developing embryo and adult tissues. Here we describe Blimp1 expression and functional requirements within maternal uterine tissues during pregnancy. Expression is robustly up-regulated at early post-implantation stages in the primary decidual zone (PDZ) surrounding the embryo. Conditional inactivation results in defective formation of the PDZ barrier and abnormal trophectoderm invasion. RNA-Seq analysis demonstrates dow...

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Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Author
ORCID:
0000-0003-3506-607X
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Division:
MSD
Sub department:
Pathology Dunn School
Role:
Author
Publisher:
Nature Research
Journal:
Nature Communications More from this journal
Volume:
11
Issue:
1
Article number:
2782
Place of publication:
England
Publication date:
2020-06-03
Acceptance date:
2020-05-11
DOI:
EISSN:
2041-1723
Pmid:
32493987
Language:
English
Keywords:
Pubs id:
1109584
Local pid:
pubs:1109584
Deposit date:
2020-06-29

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