Journal article icon

Journal article

High-resolution structural analysis of a DNA nanostructure by cryoEM.

Abstract:
Many DNA nanostructures have been produced and a wide range of potential applications have been proposed. However, confirmation of accurate 3D construction is particularly challenging. Here, we demonstrate that cryoEM may be exploited to obtain structural information at sufficient resolution to visualize the DNA helix and reveal the absolute stereochemistry of a 7 nm self-assembled DNA tetrahedron. Structural analysis at such high resolution by cryoEM image analysis is unprecedented for any biological molecule of this size.
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1021/nl901265n

Authors


Goodman, RP More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Physics, Condensed Matter Physics
Journal:
Nano letters
Volume:
9
Issue:
7
Pages:
2747-2750
Publication date:
2009-07-05
DOI:
EISSN:
1530-6992
ISSN:
1530-6984
URN:
uuid:6adb8c78-9204-4089-a3a5-9202e88e6438
Source identifiers:
11335
Local pid:
pubs:11335

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP