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Modelling variability in cardiac electrophysiology: a moment-matching approach.

Abstract:

The variability observed in action potential (AP) cardiomyocyte measurements is the consequence of many different sources of randomness. Often ignored, this variability may be studied to gain insight into the cell ionic properties. In this paper, we focus on the study of ionic channel conductances and describe a methodology to estimate their probability density function (PDF) from AP recordings. The method relies on the matching of observable statistical moments and on the maximum entropy pri...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1098/rsif.2017.0238

Authors


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ORCID:
0000-0002-1709-2787
Lombardi, D More by this author
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Institution:
University of Oxford
Division:
MPLS Division
Department:
Computer Science
Oxford college:
St Cross College
ORCID:
0000-0002-3435-7388
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ORCID:
0000-0002-4522-4329
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Grant:
NC/P001076/1
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Publisher:
Royal Society Publisher's website
Journal:
Journal of the Royal Society, Interface Journal website
Volume:
14
Issue:
133
Pages:
20170238
Publication date:
2017-08-05
Acceptance date:
2017-08-02
DOI:
EISSN:
1742-5689
ISSN:
1742-5662
Pubs id:
pubs:725912
URN:
uri:6ad8634e-d03c-4c24-a5c1-2c50744e4588
UUID:
uuid:6ad8634e-d03c-4c24-a5c1-2c50744e4588
Local pid:
pubs:725912

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