- Abstract:
-
Although genome-wide association studies (GWAS) have identified the existence of numerous population-based cancer susceptibility loci, mechanistic insights remain limited, particularly for intergenic polymorphisms. Here, we show that polymorphism at a remote intergenic region on chromosome 11q13.3, recently identified as a susceptibility locus for renal cell carcinoma, modulates the binding and function of hypoxia-inducible factor (HIF) at a previously unrecognized transcriptional enhancer of...
Expand abstract - Publisher copy:
- 10.1038/ng.2204
-
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- Journal:
- Nature Genetics
- Volume:
- 44
- Issue:
- 4
- Pages:
- 420-425
- Publication date:
- 2012-04-05
- DOI:
- EISSN:
-
1546-1718
- ISSN:
-
1061-4036
- URN:
-
uuid:6ad62192-4c19-427d-aa14-59847a53fe8f
- Source identifiers:
-
341403
- Local pid:
- pubs:341403
- Language:
- English
- Copyright date:
- 2012
Journal article
Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression
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