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Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression

Abstract:

Although genome-wide association studies (GWAS) have identified the existence of numerous population-based cancer susceptibility loci, mechanistic insights remain limited, particularly for intergenic polymorphisms. Here, we show that polymorphism at a remote intergenic region on chromosome 11q13.3, recently identified as a susceptibility locus for renal cell carcinoma, modulates the binding and function of hypoxia-inducible factor (HIF) at a previously unrecognized transcriptional enhancer of...

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Publisher copy:
10.1038/ng.2204

Authors


Schödel, J More by this author
Bardella, C More by this author
Sciesielski, LK More by this author
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Journal:
Nature Genetics
Volume:
44
Issue:
4
Pages:
420-425
Publication date:
2012-04-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:6ad62192-4c19-427d-aa14-59847a53fe8f
Source identifiers:
341403
Local pid:
pubs:341403
Language:
English

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