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Aromatic residues at the edge of the antibody combining site facilitate viral glycoprotein recognition through membrane interactions.

Abstract:

The broadly neutralizing anti-HIV antibody 4E10 recognizes an epitope very close to the virus membrane on the glycoprotein gp41. It was previously shown that epitope recognition improves in a membrane context and that 4E10 binds directly, albeit weakly, to lipids. Furthermore, a crystal structure of Fab 4E10 complexed to an epitope peptide revealed that the centrally placed, protruding H3 loop of the antibody heavy chain does not form peptide contacts. To investigate the hypothesis that the H...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0909680107

Authors


Scherer, EM More by this author
Leaman, DP More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Burton, DR More by this author
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
107
Issue:
4
Pages:
1529-1534
Publication date:
2010-01-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:6ad37137-5541-4b28-8039-8253553bf2ac
Source identifiers:
48491
Local pid:
pubs:48491

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