Exogenous high-mobility group box 1 protein induces myocardial regeneration after infarction via enhanced cardiac C-kit+ cell proliferation and differentiation.

Journal article

High-mobility group box 1 protein (HMGB1) is a chromatin protein that is released by inflammatory and necrotic cells. Extracellular HMGB1 signals tissue damage, stimulates the secretion of proinflammatory cytokines and chemokines, and modulates stem cell function. The present study examined exogenous HMGB1 effect on mouse left-ventricular function and myocyte regeneration after infarction. Myocardial infarction was induced in C57BL/6 mice by permanent coronary artery ligation. After 4 hours a...

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Authors: Limana, F; Germani, A; Zacheo, A; Kajstura, J; Di Carlo, A

• Publication status: Published
• Journal: Circulation research
• Volume: 97
• Issue: 8
• Pages: e73-e83
• Publication date: 2005-10-01
• DOI: 10.1161/01.res.0000186276.06104.04
• EISSN: 1524-4571
• ISSN: 0009-7330
• Language: English
• Keywords: Myocardial Infarction; Myocytes, Cardiac; HMGB1 Protein; Mice; Cell Differentiation; Connexin 43; Cell Proliferation; Animals; Stem Cells; Bone Marrow Cells; Regeneration; Proto-Oncogene Proteins c-kit; Ventricular Function, Left; Mice, Inbred C57BL